Mioara Larion

Mioara Larion

Dr. Mioara Larion received her B.Sc. in Biochemistry from Cuza University, Lasi, Romania in 2002. She moved to Florida State University where she received a M.Sc. in Biophysics in 2005 working on saturation transfer electron paramagnetic resonance methods and their sensitivity to molecular motion upon increasing the field. In 2009, Dr. Larion received her Ph.D. in Biochemistry working on divergent evolution of function in bacterial kinases and the origin of kinetic cooperativity in human pancreatic glucokinase in the laboratory of Prof. Brian Miller. After obtaining her Ph.D in 2009, she was awarded the AHA postdoctoral fellowship to work with Prof. Rafael Brüschweiler on biophysical characterization of glucokinase and PHHI-like variants. Her work helped understand the mechanism of glucokinase’s activation for design of better anti-diabetic therapeutics. Currently, her major interest is in metabolomics of brain tumors. In 2015, she started a metabolomics-based laboratory at National Cancer Institute, to work on isocitrate dehydrogenase mutant brain tumors. Dr. Larion’s work on understanding metabolic reprograming of lower grade gliomas in the indolent and progressed state has identified imaging and therapeutic targets.