Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Monash University, Parkville Campus
381 Royal Parade, Parkville, Vic, 3052
Dr Darren Creek is a NHMRC CJ Martin Research Fellow in the Department of Biochemistry and Molecular Biology at the University of Melbourne. Darren completed his PhD in pharmaceutics at Monash University in 2008, which involved applications of LCMS and spectroscopic methods to support the discovery of novel antimalarials, arterolane and OZ439. He then conducted post-doctoral research on clinical pharmacology of malaria with the University of California San Francisco and Makerere University in Uganda, and returned to Australia to investigate drug metabolism at the Centre for Drug Candidate Optimisation. On being awarded the NHMRC CJ Martin fellowship, Darren moved to Glasgow University, UK, where he played a major role in the implementation of the Scottish Metabolomics Facility. Darren has developed numerous analytical and bioinformatic methods to optimise outcomes from LCMS and GCMS based untargeted metabolomics studies, and his major contributions to the metabolomics field include: retention time prediction for metabolite identification, untargeted stable-isotope labelling for pathway discovery, and the user-friendly, open-source software for identification and evaluation of metabolomics data, IDEOM. His research has demonstrated the power of metabolomics for the unbiased discovery of novel enzymes, pathways and mechanisms of drug action, and he continues to develop metabolomics techniques, and apply metabolomics to parasitology, microbiology and pharmacology. Darren has over 30 peer-reviewed publications and maintains collaborations across all 6 continents that apply metabolomics to address important issues in biomedical research.